To control the tumor microenvironment

TME and Soluble Factors

Cancers consist mainly of malignant cells, non-malignant cells and extracellular matrix (ECM). Interactions between malignant and non- malignant cells are mediated by soluble factors. Many soluble factors in the TME contribute to success of cancer chemotherapy. Active molecules that contribute to cancer treatment clinically are listed below. Non-cellular molecules such as VEGF, EGF, EGFR, FGF, PDGF, TGF-β, TNF-α, HGF, NF-κB are known. These are exactly in agreement with the target of drugs called molecular targeted drugs. Cancer therapy cannot be established without drugs that act on these factors such as VEGF at high rates and effectively. By knowing the action of each factor, it is possible to control cancer cells with molecular targeted drugs. This treatment is called molecular targeted chemotherapy. It is important for chemotherapy to start immediately as soon as cancer is detected with molecular targeted drugs. Absolutely do not start molecular targeted chemotherapy in accordance with Japanese ambiguous standard chemotherapy.